General Information:

Id: 7,511
Diseases: Diabetes mellitus, type II - [OMIM]
Inflammatory bowel disease
Insulin resistance
Mus musculus
article
Reference: Arsenescu R et al.(2011) Role of the xenobiotic receptor in inflammatory bowel disease Inflamm. Bowel Dis. 17: 1149-1162 [PMID: 20878756]

Interaction Information:

Comment AhR-/- mice died before the end of the treatment. However, AhR-/+ mice exhibited decreased disease activity compared to WT mice. The AhR-/+ mice expressed less proinflammatory cytokines such as tumor necrosis factor alpha (TNF-alpha) and IL17 and increased antiinflammatory IL-10 compared with the AhR+/+ mice in the colon.
Formal Description
Interaction-ID: 74107

gene/protein

AHR

affects_expression of

gene/protein

TNF

in the colon
Drugbank entries Show/Hide entries for AHR or TNF
Comment AhR-/- mice died before the end of the treatment. However, AhR-/+ mice exhibited decreased disease activity compared to WT mice. The AhR-/+ mice expressed less proinflammatory cytokines such as tumor necrosis factor alpha (TNF-alpha) and IL17 and increased antiinflammatory IL-10 compared with the AhR+/+ mice in the colon.
Formal Description
Interaction-ID: 74109

gene/protein

AHR

affects_expression of

gene/protein

IL17A

in the colon
Drugbank entries Show/Hide entries for AHR
Comment AhR-/- mice died before the end of the treatment. However, AhR-/+ mice exhibited decreased disease activity compared to WT mice. The AhR-/+ mice expressed less proinflammatory cytokines such as tumor necrosis factor alpha (TNF-alpha) and IL17 and increased antiinflammatory IL-10 compared with the AhR+/+ mice in the colon.
Formal Description
Interaction-ID: 74110

gene/protein

AHR

affects_expression of

gene/protein

IL10

in the colon
Drugbank entries Show/Hide entries for AHR
Comment AhR-/- mice died before the end of the treatment. However, AhR-/+ mice exhibited decreased disease activity compared to WT mice. The AhR-/+ mice expressed less proinflammatory cytokines such as tumor necrosis factor alpha (TNF-alpha) and IL17 and increased antiinflammatory IL-10 compared with the AhR+/+ mice in the colon.
Formal Description
Interaction-ID: 74111

gene/protein

AHR

affects_activity of

process

inflammatory response

in the colon
Drugbank entries Show/Hide entries for AHR
Comment Colonic macrophage infiltration was attenuated in the AhR-/+ group.
Formal Description
Interaction-ID: 74112

gene/protein

AHR

affects_quantity of

tissue/cell line

macrophage

in the colon
Drugbank entries Show/Hide entries for AHR
Comment Adiponectin, the only known anti-inflammatory adipokine, is considered an exclusive product of adipose tissue. The study shows that adiponectin gene is also expressed in the colon.
Formal Description
Interaction-ID: 74116

gene/protein

ADIPOQ

is_expressed_in

tissue/cell line

colon

Comment AhR-/+ mice treated with DSS presented a significant downregulation of the only known precursor of angiotensin I/II - angiotensinogen, as well as the angiotensin converting enzyme ACE, and angiotensin receptor AT1 gene expression compared to the WT group. Importantly, the AhR-/+ mice presented significant less AT1 mRNA gene expression under basal conditions. Compared to WT mice with colitis, the immunohistochemistry of colon sections of AhR-/+ mice with colitis revealed decreased angiotensin II, AT1 receptor and ACE expression.
Formal Description
Interaction-ID: 74117

gene/protein

AHR

affects_expression of

gene/protein

AGT

Drugbank entries Show/Hide entries for AHR
Comment AhR-/+ mice treated with DSS presented a significant downregulation of the only known precursor of angiotensin I/II - angiotensinogen, as well as the angiotensin converting enzyme ACE, and angiotensin receptor AT1 gene expression compared to the WT group. Importantly, the AhR-/+ mice presented significant less AT1 mRNA gene expression under basal conditions. Compared to WT mice with colitis, the immunohistochemistry of colon sections of AhR-/+ mice with colitis revealed decreased angiotensin II, AT1 receptor and ACE expression.
Formal Description
Interaction-ID: 74118

gene/protein

AHR

affects_expression of

gene/protein

ACE

Drugbank entries Show/Hide entries for AHR or ACE
Comment AhR-/+ mice treated with DSS presented a significant downregulation of the only known precursor of angiotensin I/II - angiotensinogen, as well as the angiotensin converting enzyme ACE, and angiotensin receptor AT1 gene expression compared to the WT group. Importantly, the AhR-/+ mice presented significant less AT1 mRNA gene expression under basal conditions. Compared to WT mice with colitis, the immunohistochemistry of colon sections of AhR-/+ mice with colitis revealed decreased angiotensin II, AT1 receptor and ACE expression.
Formal Description
Interaction-ID: 74119

gene/protein

AHR

affects_expression of

gene/protein

AGTR1

Drugbank entries Show/Hide entries for AHR or AGTR1
Comment All the AhR-/+ mice presented a higher basal adiponectin mRNA gene expression that did not change during treatment.
Formal Description
Interaction-ID: 74120

gene/protein

AHR

affects_expression of

gene/protein

ADIPOQ

Drugbank entries Show/Hide entries for AHR
Comment Adiponectin mRNA gene expression dropped significantly in the wild type mice during colitis. Consequently, adiponectin receptors (AdipoQ R1 and R2) were downregulated during DSS colitis in all groups.
Formal Description
Interaction-ID: 74122

phenotype

colitis

decreases_expression of

gene/protein

ADIPOQ

Comment Adiponectin mRNA gene expression dropped significantly in the wild type mice during colitis. Consequently, adiponectin receptors (AdipoQ R1 and R2) were downregulated during DSS colitis in all groups.
Formal Description
Interaction-ID: 74124

phenotype

colitis

decreases_expression of

gene/protein

ADIPOR1

Comment Adiponectin mRNA gene expression dropped significantly in the wild type mice during colitis. Consequently, adiponectin receptors (AdipoQ R1 and R2) were downregulated during DSS colitis in all groups.
Formal Description
Interaction-ID: 74125

phenotype

colitis

decreases_expression of

gene/protein

ADIPOR2

Comment T-Cadherin mRNA gene expression, a novel adiponectin receptor that serves to anchor adiponectin to cell surface, was upregulated only in the AhR-/+ mice and not in the WT mice with colitis.
Formal Description
Interaction-ID: 74126

gene/protein

AHR

affects_expression of

gene/protein

CDH13

Drugbank entries Show/Hide entries for AHR
Comment AhR-/+ mice exposed to DSS had a lower expression of Protein of 44 kDa [Erp44] that inhibits the secretion of adiponectin oligomers from the endoplasmic reticulum [ER].
Formal Description
Interaction-ID: 74129

gene/protein

AHR

affects_expression of

gene/protein

ERP44

Drugbank entries Show/Hide entries for AHR
Comment A significant downregulation of ER stress markers BIP and XBP1 was observed in the AhR-/+ mice exposed to DSS as compared to the WT mice with colitis.
Formal Description
Interaction-ID: 74131

gene/protein

AHR

affects_expression of

gene/protein

HSPA5

Drugbank entries Show/Hide entries for AHR or HSPA5
Comment A significant downregulation of ER stress markers BIP and XBP1 was observed in the AhR-/+ mice exposed to DSS as compared to the WT mice with colitis.
Formal Description
Interaction-ID: 74134

gene/protein

AHR

affects_expression of

gene/protein

XBP1

Drugbank entries Show/Hide entries for AHR
Comment Since ER stress response is coupled to the cell death program, the mRNA expression of two pro-apoptotic molecules was investigated: C/EBP Homologous Protein [CHOP] and Caspase 12 [Casp12]. There was a significant downregulation of the expression of both pro-apoptotic genes only in the AhR-/+ mice exposed to DSS.
Formal Description
Interaction-ID: 74135

gene/protein

AHR

affects_expression of

gene/protein

DDIT3

Drugbank entries Show/Hide entries for AHR
Comment Since ER stress response is coupled to the cell death program, the mRNA expression of two pro-apoptotic molecules was investigated: C/EBP Homologous Protein [CHOP] and Caspase 12 [Casp12]. There was a significant downregulation of the expression of both pro-apoptotic genes only in the AhR-/+ mice exposed to DSS.
Formal Description
Interaction-ID: 74136

gene/protein

AHR

affects_expression of

gene/protein

CASP12

Drugbank entries Show/Hide entries for AHR