General Information:

Id: 469
Diseases: Parkinson disease
Homo sapiens
PD patients with LRRK2-G2019S mutation
BTO:0000751 leukocyte
article
Reference: White LR et al.(2007) MAPK-pathway activity, Lrrk2 G2019S, and Parkinsons disease J. Neurosci. Res. 85: 1288-1294 [PMID: 17385669]

Interaction Information:

Comment Total amount of Src and phosphorylated Src was reduced in patients carrying the G2019S mutation in LRRK2, as well as in the idiopathic PD group compared to healthy people.
Formal Description
Interaction-ID: 2134

disease

Parkinson disease

decreases_quantity of

gene/protein

SRC

Drugbank entries Show/Hide entries for SRC
Comment Total amount of Src and phosphorylated Src was reduced in patients carrying the G2019S mutation in LRRK2, as well as in the idiopathic PD group compared to healthy people.
Formal Description
Interaction-ID: 2136

disease

Parkinson disease

decreases_phosphorylation of

gene/protein

SRC

Drugbank entries Show/Hide entries for SRC
Comment In patients carrying the G2019S mutation in LRRK2, as well as in the idiopathic PD group the level of phosphorylated HSP27 was reduced compared to healthy people. There were no differences between the groups for total HSP27.
Formal Description
Interaction-ID: 2137

disease

Parkinson disease

decreases_phosphorylation of

gene/protein

HSPB1

Comment In patients carrying the G2019S mutation in LRRK2, as well as in the idiopathic PD group the level of phosphorylated HSP27 was reduced compared to healthy people. There were no differences between the groups for total HSP27.
Formal Description
Interaction-ID: 2138

disease

Parkinson disease

NOT decreases_quantity of

gene/protein

HSPB1

Comment In patients with LRRK2-G2019S-associated PD a reduction of phosphorylated JNK was found compared to healthy people. There were no differences between the groups for total JNK.
Formal Description
Interaction-ID: 2141

disease

Parkinson disease

decreases_phosphorylation of

gene/protein

MAPK8

Drugbank entries Show/Hide entries for MAPK8
Comment In patients with LRRK2-G2019S-associated PD a reduction of phosphorylated JNK was found compared to healthy people. There were no differences between the groups for total JNK.
Formal Description
Interaction-ID: 2142

disease

Parkinson disease

NOT decreases_quantity of

gene/protein

MAPK8

Drugbank entries Show/Hide entries for MAPK8
Comment LRRK2-mutation G2019S alters cellular MAPK signaling cascades.
Formal Description
Interaction-ID: 10823

gene/protein mutant

LRRK2-p.G2019S

affects_activity of

process

stress-activated MAPK cascade

Comment LRRK2-mutation G2019S alters cellular MAPK signaling cascades.
Formal Description
Interaction-ID: 10824

disease

Parkinson disease

affects_activity of

process

stress-activated MAPK cascade