General Information:

Id: 14,973
Diseases: Ciliopathy
Homo sapiens
article
Reference: [PMID: 26297806]

Interaction Information:

Comment Primary microcephaly (MCPH) associated proteins CDK5RAP2, CEP152, WDR62 and CEP63 colocalize at the centrosome. The authors found that they interact to promote centriole duplication and form a hierarchy in which each is required to localize another to the centrosome, with CDK5RAP2 at the apex, and CEP152, WDR62 and CEP63 at sequentially lower positions. MCPH proteins interact with distinct centriolar satellite proteins; CDK5RAP2 interacts with SPAG5 and CEP72, CEP152 with CEP131, WDR62 with MOONRAKER, and CEP63 with CEP90 and CCDC14.
Formal Description
Interaction-ID: 140306

gene/protein

CDK5RAP2

interacts (colocalizes) with

gene/protein

SPAG5

Comment Primary microcephaly (MCPH) associated proteins CDK5RAP2, CEP152, WDR62 and CEP63 colocalize at the centrosome. The authors found that they interact to promote centriole duplication and form a hierarchy in which each is required to localize another to the centrosome, with CDK5RAP2 at the apex, and CEP152, WDR62 and CEP63 at sequentially lower positions. MCPH proteins interact with distinct centriolar satellite proteins; CDK5RAP2 interacts with SPAG5 and CEP72, CEP152 with CEP131, WDR62 with MOONRAKER, and CEP63 with CEP90 and CCDC14.
Formal Description
Interaction-ID: 140307

gene/protein

CDK5RAP2

interacts (colocalizes) with

gene/protein

CEP72

Comment Primary microcephaly (MCPH) associated proteins CDK5RAP2, CEP152, WDR62 and CEP63 colocalize at the centrosome. The authors found that they interact to promote centriole duplication and form a hierarchy in which each is required to localize another to the centrosome, with CDK5RAP2 at the apex, and CEP152, WDR62 and CEP63 at sequentially lower positions. MCPH proteins interact with distinct centriolar satellite proteins; CDK5RAP2 interacts with SPAG5 and CEP72, CEP152 with CEP131, WDR62 with MOONRAKER, and CEP63 with CEP90 and CCDC14.
Formal Description
Interaction-ID: 140308

gene/protein

CEP152

interacts (colocalizes) with

gene/protein

CEP131

Comment Primary microcephaly (MCPH) associated proteins CDK5RAP2, CEP152, WDR62 and CEP63 colocalize at the centrosome. The authors found that they interact to promote centriole duplication and form a hierarchy in which each is required to localize another to the centrosome, with CDK5RAP2 at the apex, and CEP152, WDR62 and CEP63 at sequentially lower positions. MCPH proteins interact with distinct centriolar satellite proteins; CDK5RAP2 interacts with SPAG5 and CEP72, CEP152 with CEP131, WDR62 with MOONRAKER, and CEP63 with CEP90 and CCDC14.
Formal Description
Interaction-ID: 140309

gene/protein

WDR62

interacts (colocalizes) with

gene/protein

KIAA0753

Comment Primary microcephaly (MCPH) associated proteins CDK5RAP2, CEP152, WDR62 and CEP63 colocalize at the centrosome. The authors found that they interact to promote centriole duplication and form a hierarchy in which each is required to localize another to the centrosome, with CDK5RAP2 at the apex, and CEP152, WDR62 and CEP63 at sequentially lower positions. MCPH proteins interact with distinct centriolar satellite proteins; CDK5RAP2 interacts with SPAG5 and CEP72, CEP152 with CEP131, WDR62 with MOONRAKER, and CEP63 with CEP90 and CCDC14.
Formal Description
Interaction-ID: 140310

gene/protein

CEP63

interacts (colocalizes) with

gene/protein

PIBF1

Comment Primary microcephaly (MCPH) associated proteins CDK5RAP2, CEP152, WDR62 and CEP63 colocalize at the centrosome. The authors found that they interact to promote centriole duplication and form a hierarchy in which each is required to localize another to the centrosome, with CDK5RAP2 at the apex, and CEP152, WDR62 and CEP63 at sequentially lower positions. MCPH proteins interact with distinct centriolar satellite proteins; CDK5RAP2 interacts with SPAG5 and CEP72, CEP152 with CEP131, WDR62 with MOONRAKER, and CEP63 with CEP90 and CCDC14.
Formal Description
Interaction-ID: 140311

gene/protein

CEP63

interacts (colocalizes) with

gene/protein

CCDC14

Comment Consistent with a role for satellites in microcephaly, homozygous mutations in one satellite gene, CEP90, may cause Primary microcephaly (MCPH). Examination of whole exome sequence from >300 families with MCPH identified a homozygous missense variant in CEP90 in a consanguineous Pakistani family with two affected male siblings.
Formal Description
Interaction-ID: 140312

gene/protein

PIBF1

affects_activity of

phenotype

microcephaly

Comment Centriolar satellite proteins CEP72 and SPAG5 are required for MCPH-associated protein CDK5RAP2 to localize to the centrosome.
Formal Description
Interaction-ID: 140313

gene/protein

CEP72

increases_quantity of

gene/protein

CDK5RAP2

in the centrosome
Comment Centriolar satellite proteins CEP72 and SPAG5 are required for MCPH-associated protein CDK5RAP2 to localize to the centrosome.
Formal Description
Interaction-ID: 140314

gene/protein

SPAG5

increases_quantity of

gene/protein

CDK5RAP2

in the centrosome
Comment Centriolar satellite protein CEP131 is required for MCPH-associated protein CEP152 to localize to the centrosome.
Formal Description
Interaction-ID: 140315

gene/protein

CEP131

increases_quantity of

gene/protein

CEP152

in the centrosome
Comment Centriolar satellite protein MOONRAKER is required for MCPH-associated protein WDR62 to localize to the centrosome.
Formal Description
Interaction-ID: 140316

gene/protein

KIAA0753

increases_quantity of

gene/protein

WDR62

in the centrosome
Comment Centriolar satellite protein CEP90 is required for MCPH-associated protein CEP63 to localize to the centrosome.
Formal Description
Interaction-ID: 140317

gene/protein

PIBF1

increases_quantity of

gene/protein

CEP63

in the centrosome
Comment Centriolar satellite component CCDC14 restrains the centrosomal accumulation of CEP63 and CDK2.
Formal Description
Interaction-ID: 140318

gene/protein

CCDC14

affects_quantity of

gene/protein

CEP63

in the centrosome
Comment Centriolar satellite component CCDC14 restrains the centrosomal accumulation of CEP63 and CDK2.
Formal Description
Interaction-ID: 140319

gene/protein

CCDC14

affects_quantity of

gene/protein

CDK2

in the centrosome
Drugbank entries Show/Hide entries for CDK2